Symbol
Name
ID

Adam17
a disintegrin and metallopeptidase domain 17
MGI:1096335

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

enhanced leukocyte tethering or rolling

increased susceptibility to induced colitis

enlarged spleen

myeloid hyperplasia

increased neutrophil cell number

decreased B cell number

increased T-helper 1 cell number

increased T-helper 17 cell number

increased T-helper 2 cell number

decreased T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased leukocyte cell number

abnormal spleen morphology

increased spleen red pulp amount

increased IgE level

abnormal macrophage physiology

abnormal circulating chemokine level

increased circulating interleukin-17 level

decreased circulating tumor necrosis factor level

abnormal chemokine level

abnormal dendritic cell physiology

abnormal interleukin secretion

increased interleukin-10 secretion

increased interleukin-17 secretion

decreased susceptibility to endotoxin shock

increased incidence of corneal inflammation

skin inflammation

dermatitis

Availability

Mouse Genotype

Adam17^m1Btlr/Adam17^m1Btlr

Adam17^tm1.1Srj/Adam17^tm1.1Srj

Adam17^tm1Ckww/Adam17^tm1Ckww

Adam17^tm1Imx/Adam17^tm1Imx

Adam17^tm1Rain/Adam17^tm1Rain

Adam17^woe/Adam17^woe

Adam17^{tm1a(EUCOMM)Wtsi}/Adam17⁺

Adam17^tm1.2Bbl/Adam17^tm1.2Bbl
Sox9^tm3(cre)Crm/Sox9⁺ (conditional)

Adam17^tm1Bbl/Adam17^tm1Bbl
Lyz2^tm1(cre)Ifo/0 (conditional)

Adam17^tm1Bbl/Adam17^tm1Bbl
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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